Offres d’Emploi – PostDoc

Les offres proposées émanent des laboratoires du Département Scientifique Biologie-Santé ou de leurs collaborateurs en France ou à l’étranger. Vous trouverez d’autres offres sur des sites plus spécialisés:

  • Le Réseau professionnel de l’Université de MONTPELLIER: ResUM
  • Accès Doctorat Unique et Mutualisé: ADUM
  • Écoles Doctorales Sciences chimiques et Biologiques pour la Santé: CBS2, ED 168
  • Écoles Doctorales Sciences du Mouvement Humain: SMH, ED 463
  • Association Bernard Gregory: ABG

Les offres sont présentées par date de publication sur le site.

21/09/2017 – Postdoctoral position in CD4+ T cell biology in Nice, France

  • Type : Postdoc
  • Contrat: 12 mois
  • Deadline: 30 October 2017

 

Host laboratory:  The team « Osteoimmunology, niches and inflammation » in the
Laboratory of Molecular PhysioMedicine, Nice, France (http://unice.fr/lp2m/fr/lesequipes/
osteoimmunologie-niche-inflammation-c-blin) is depending on the CNRS, the main
research body in France, and the University of Nice labeled as « University of Excellence ».
Located in the Faculty of Medicine in the heart of Nice, it provides a high-quality scientific
environment with access to all required core facilities as well as interaction with clinicians.
Project:
The research activities of the team are focused on the cellular interactions between immune and
non-immune cells and in particular in the dialog between the bone marrow and the gut. The
postdoctoral researcher will work on the effect of biotherapies on CD4+ T cell polarization in
relation with microbiota dysbiosis. The project combines analysis in vitro, in vivo in a murine
model of inflammatory bowel disease and in patients affected with Crohn’s disease.

More information

To apply:
Applicants should submit (in French or in English) their CV and publication list, the name and email
of 3 references and a brief statement of past achievements and research interests to Dr Wakkach (wakkach@unice.fr).

21/09/2017 – Postdoctoral position in osteoimmunology in Nice, France

  • Type : Postdoc
  • Contrat: 24-36 mois
  • Deadline:30 Octobre 2017

 

Host laboratory: The team « Osteoimmunology, niches and inflammation » in the
Laboratory of Molecular PhysioMedicine, Nice, France (http://unice.fr/lp2m/fr/lesequipes/
osteoimmunologie-niche-inflammation-c-blin) is depending on the CNRS, the main
research body in France, and the University of Nice labeled as « University of Excellence ».
Located in the Faculty of Medicine in the heart of Nice, it provides a high-quality scientific
environment with access to all required core facilities as well as interaction with clinicians.
Project:
The research activities of the team are focused on the cellular interactions between immune and
non-immune cells in the bone marrow. Among these cells, osteoclasts are moncytic boneresorbing
cells responsible for bone destruction in many chronic inflammatory diseases. We have
recently shown that their function is not limited to bone resorption and that depending on their
origin and environment, they induce immunosuppressive or inflammatory responses.

More information

To apply:
Applicants should submit (in French or in English) their CV and publication list, the name and email
of 3 references and a brief statement of past achievements and research interests to Dr Blin (blin@unice.fr).

08/09/2017 – Poste d’ATER, Université ULCO, Boulogne sur Mer

  • Type : ATER

Le laboratoire Physiopathologie des Maladies Osseuses Inflammatoires de Boulogne recherche un candidat pour un poste ATER vacant.

L’ATER poursuivra un projet de recherche relatif à l’étude des fonctions sécrétrices des adipocytes médullaires sur le remodelage osseux par des approches classiques à partir de modèles
cellulaire et/ou murins disponibles au laboratoire.

Enseignement
– Filières de formation concernées : L1-L2-L3 Sciences Technologies Santé mention Sciences de la Vie ; DEUST Technicien de la Mer et du Littoral. Les enseignements s’effectuent au Centre de la Mi-Voix à Calais.
– Objectifs pédagogiques :Il s’agit de renforcer l’équipe pédagogique sur des enseignements de Biologie cellulaire, Biologie moléculaire, biologie générale, physiologie cellulaire, génétique. La personne recrutée s’impliquera dans des formes d’enseignements diverses (CM, TD, TP, TPE). Elle devra se sentir concernée par la complémentarité des formes d’enseignements et notamment les nouvelles approches pédagogiques au service de la réussite des étudiants.

Recherche :
Le laboratoire Physiopathologie des Maladies Osseuses Inflammatoires (PMOI, EA 4490, IFR 114) est une unité de recherche pluridisciplinaire sur le tissu osseux localisée sur deux sites (Lille et
Boulogne-sur-Mer). La thématique de recherche du laboratoire est notamment centrée sur l’implication des adipocytes médullaires dans la diminution de la masse osseuse. En effet, dans l’ostéoporose, la perte osseuse est classiquement associée à un déséquilibre entre la résorption osseuse (réalisée par les ostéoclastes) et la formation osseuse (assurée par les ostéoblastes). Au cours de ces dernières années, les adipocytes de la moelle osseuse se sont révélés être de nouveaux acteurs cellulaires contribuant également à ce déséquilibre par la sécrétion de plusieurs facteurs protéiques. Mieux définir comment les adipocytes médullaires altèrent l’homéostasie osseuse est donc devenu un enjeu scientifique et médical crucial.
Dans ce contexte, le laboratoire PMOI impulse et participe à la structuration de la recherche sur l’adiposité médullaire au niveau national et européen (organisation de congrès, constitution de
réseaux, projets collaboratifs…). Le PMOI développe plusieurs approches à partir de modèles cellulaire (Cellules Souches Mésenchymateuses CSM humaines) et animaux (le modèle murin
d’ostéoporose ménopausique par ovariectomie notamment), de prélèvements pathologiques humains pour définir les facteurs sécrétés par les adipocytes médullaires qui impactent sur le remodelage osseux.
La personne recrutée aura pour mission la poursuite d’un des projets relatifs à l’étude des fonctions sécrétrices des adipocytes médullaires par des approches classiques de biologie moléculaire
(PCR en temps réel, western-blot, ELISA, SiRNA…) à partir de modèles de biologie cellulaire (adipocytes et ostéoblastes différenciés des CSM humaines) ou de modèles murins.

La campagne de recrutement est du 06 septembre au 27 septembre pour le dépôt de dossiers. Les candidats intéressés doivent donc contacter le plus rapidement possible Christophe Chauveau ou 03 21 99 45 19.

04/09/2017 – Postdoc position or IE, IBPC, Paris

  • Type : Post-doc
  • Contrat : 24 months

 

Postdoctoral position
The group of Dr Carine Tisné is inviting applications for a postdoctoral associate position in the area of RNA biogenesis and maturation at the Institute of Biology and Physical chemistry
IBPC) in Paris (http://www.ibpc.fr/UMR8261/equipeTisne/AccueilTisne.htm).
The research project involves the structural investigation of biomolecules inside living cells with Nuclear Magnetic Resonance spectroscopy (NMR). Candidates must hold a PhD in biochemistry, structural biology, or microbiology. Experience in RNA sample preparation by in vitro methods or in yeast genetics and molecular biology will be an asset. Knowledge in biomolecular NMR, and in RNA structural studies would be appreciated but is not required. In that case, motivation to learn biomolecular NMR techniques is essential. Excellent communication skills in English or French, ability to work in multi-disciplinary teams and scientific creativity are essential. We offer an exciting and enthusiastic work environment together with a stimulating location at the center of Paris
(close to “Jardin du Luxembourg”).
To be considered, all applicants need to submit a cover letter, curriculum vitae with full publication list, 1-2 representative publications, and 2-3 contacts of scientists with whom the
candidate has been working, all in PDF format. Letters of support may be asked at a further stage of selection. If you have any questions, please email Dr. Carine Tisné and/or Dr. Pierre Barraud.
The position offers a one-year contract with a possible renewal for another year in case of mutual interest. The anticipated appointment starting date is September 1 st , 2017.
Applications will be accepted immediately and candidates will be considered on a rolling basis until the position is filled.

04/09/2017 – Postdoc position, CRCL, Lyon

  • Type : Post-doc
  • Contrat : 18 months

Post-doctoral position: “Overcoming resistance to ibrutinib”

We propose a post-doctoral position for one and a half year in our team located in Lyon Sud campus.

Project: B cell lymphomas are a heterogeneous group of cancers arising from B lymphocytes. Most of them are dependent on the signals from their antigen receptor (B cell receptor, BCR) for their survival and proliferation. Hence, inhibitors of the signaling pathways downstream the BCR have been developed, such as ibrutinib, the first inhibitor of the Bruton Tyrosine kinase (BTK). Despite impressive response rates, relapses occur driven by ibrutinib resistant clones carrying the C481S mutation of BTK. The outcome of patients harboring this mutation is very poor.

This work explores two strategies to overcome ibrutinib resistance:

Collateral sensitivity The concept of collateral sensitivity means that a mutation of a kinase conferring resistance to an inhibitor might create an unexpected sensitivity to another inhibitor. This concept has been validated with axitinib in T315I mutated BCR-ABL. We have established a cell line whose survival is strictly dependent on BTK or BTK-C481S. This cell line has already been use in a screen of all the FDA-approved chemical compounds (Prestwick library) and is now used in a screen of kinase inhibitors. We have also established genetically modified lymphoma cell lines for validations of interesting hits.

Non-oncogenic addiction To survive to the stress created by the activation of oncogenes, cancer cells rely on stress pathways that might be therapeutically targeted. The objective of this project is to determine what are the non-oncogenic addictions created by the activation of the BCR pathway, with a whole genome CRISPR/Cas9 screen in a lymphoma cell line with or without overactivation of the BCR. Our first attempts to activate the BCR pathway with a constitutively activated mutation of BTK were not conclusive, and this model needs to be improved. The use of whole genome CRISPR/Cas9 screen is already ongoing in the team for other projects.

The Team The team “Clinical and experimental models of lymphomagenesis”, headed by Laurent Genestier and Gilles Salles, belongs to the Centre de Recherche en Cancérologie de Lyon (CRCL). This teams comprises full time researchers and medical doctors, as well as post-doctoral researchers, doctorants and ingeneers, and develop in vitro and in vivo models of lymphomas to understand lymphomagenesis and develop therapies.

Contact

29/08/2017 – Postdoc position: maturation des ARN, Institut de biologie physico-chimique, UMR8261 CNRS/université Paris Diderot, Paris

  • Type : Post-doc
  • Contrat : 12 months with possible renewal
  • Expected starting date : 1 st september 2017

The group of Dr Carine Tisné is inviting applications for a postdoctoral associate position in the area of RNA biogenesis and maturation at the Institute of Biology and Physical chemistry IBPC) in Paris (http://www.ibpc.fr/UMR8261/equipeTisne/AccueilTisne.htm).
The research project involves the structural investigation of biomolecules inside living cells with Nuclear Magnetic Resonance spectroscopy (NMR).

More information

To be considered, all applicants need to submit a cover letter, curriculum vitae with full publication list, 1-2 representative publications, and 2-3 contacts of scientists with whom the candidate has been working, all in PDF format. Letters of support may be asked at a further stage of selection. If you have any questions, please email Dr. Carine Tisné
(carine.tisne@ibpc.fr) and/or Dr. Pierre Barraud (pierre.barraud@ibpc.fr).

25/08/2017 – Post-doctoral position: Overcoming resistance to ibrutinib – Centre de Recherche en Cancérologie, Lyon

  • Type : Post-doc
  • Contrat : 18 months

Project:
B cell lymphomas are a heterogeneous group of cancers arising from B lymphocytes. Most of them are dependent on the signals from their antigen receptor (B cell receptor, BCR) for their survival and proliferation. Hence, inhibitors of the signaling pathways downstream the BCR have been developed, such as ibrutinib, the first inhibitor of the Bruton Tyrosine kinase (BTK). Despite impressive response rates, relapses occur driven by ibrutinib resistant clones carrying the C481S mutation of BTK. The outcome of patients harboring this mutation is very poor.

The Team
The team “Clinical and experimental models of lymphomagenesis”, headed by Laurent Genestier and Gilles Salles, belongs to the Centre de Recherche en Cancérologie de Lyon (CRCL). This teams comprises full time researchers and medical doctors, as well as post-doctoral researchers, doctorants and ingeneers, and develop in vitro and in vivo models of lymphomas to understand lymphomagenesis and develop therapies.

More information

Contact : pierre.sujobert@chu-lyon.fr
tel 06 64 77 59 12

02/08/2017 – Postdoc position at IGH, Montpellier

  • Type : Post-doc
  • Contrat : 24 months

Functions of the piRNA pathway in germline stem cells
A two-year post-doctoral position funded by the Labex EpiGenMed is available in the group mRNA Regulation and Development at the Institute of Human Genetics in Montpellier (http://www.igh.cnrs.fr/EN/equipe-detail.php?id=20). Our lab works on gene regulation at the mRNA level during development and diseases, in the Drosophila model. We have described the role of Piwi-interacting RNAs (piRNAs), a specific class of small non-coding RNAs, in gene regulation for several developmental processes. This function was unexpected because piRNAs were thought to be specific to the regulation of transposable elements. piRNAs and PIWI proteins are highly expressed in germ cells and stem cell lineages. The post-doctoral project aims at understanding the functions of the piRNA pathway in stem cells, using germline stem cells as a model system.
The Institute of Human Genetics provides a very stimulating and international research environment; it is fully endowed with state-of-the-art scientific equipment. The Institute is located in Montpellier, an international city in the South of France. http://www.igh.cnrs.fr/
We are looking for very motivated and ambitious candidates with strong expertise in Drosophila genetics, imaging, metabolism, or RNA biology.
Candidates should apply by sending a CV, a short outline of current projects, and contact information of two to three references to Martine Simonelig.
Expected starting date of the contract: October 1st, 2017.

Selected publications of the lab, related to the project:
Rojas Ríos P*, Chartier A*, Pierson S, Séverac D, Dantec C, Busseau I, Simonelig M. Translational control of
autophagy by Orb in the Drosophila germline (2015) Developmental Cell, 35, 622-631
Barckmann B, Pierson S, Dufourt J, Papin C, Armenise C, Port F, Grentzinger T, Chambeyron S, Baronian G,
Desvignes JP, Curk T, Simonelig M. Aubergine iCLIP reveals piRNA-dependent decay of mRNAs involved in
germ cell development in the early embryo (2015) Cell Reports,12,1205-16
Simonelig M. piRNAs, master regulators of gene expression (2014) Cell Research, 24, 779-80
Joly W, Chartier A, Rojas-Rios P, Busseau I, Simonelig M. The CCR4 deadenylase acts with Nanos and Pumilio
in the fine-tuning of Mei-P26 expression to promote germline stem cell self-renewal (2013) Stem Cell Reports,
1, 411-424
Rouget C, Papin C, Boureux A, Meunier A-C, Franco B, Robine N, Lai EC., Pélisson A, Simonelig M. Maternal
mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo (2010) Nature, 467,
1128-1132

02/08/2017 – Assistant Professor in Neurosciences – Neurooncology, Normandie Rouen University

  • Type : Permanent

Assistant Professor in Neurosciences-Neuro-oncology at the Normandie Rouen University
The University of Rouen Normandie nurtures internationally strong social and economic links in the fields of energies, aeronautics, logistics, transports and mobility, cosmetology and
health. It plays a major role in terms of innovation, through learning institutes, clusters and competitive hubs. The Institute for Research and Innovation in Biomedicine (IRIB –
FED4220) is a Federative Structure of Research regrouping all the resources of biomedical research in Haute-Normandie with the objective to develop a high-level biomedical research
particularly focused on the understanding of disease physiopathology and the development of new diagnostic and therapeutic tools thanks to the complementarities of clinicians, biologists
and chemists of the Normandie Rouen University.

Tenure track as Assistant Professor in Neurosciences- Neuro-oncology
Required basic qualifications:
Candidates must have a PhD or equivalent degree at the time of application. French candidates must be qualified in one of the following sections: 65, Biologie cellulaire; 66, Physiologie; 69, Neurosciences.

Research
The candidate will join the team Astrocyte and Vascular Niche within the UMR1239 INSERM, DC2N, Rouen. The general objective of the project is to tackle the glial tumor-brain interface in an original angle by developing molecular and cellular approaches and animal models, particularly by means of electrophysiological and in vivo brain imaging. The candidate must possess a solid expertise in neurophysiology, cell signaling with skills in electrophysiological techniques and/or dynamic imaging in vivo. The mastery of molecular tools to target brain/tumor cell populations will be a plus. The candidate will have free access to the local platforms and services of imaging, proteomic, genomic of IRIB federation, to the expertise of the team and of the platform Cancer and Cognition, and will benefit from the infrastructures available in the central animal facility of the UFR Sciences and Techniques.

Teaching
The Assistant professor will teach in the field of Neurosciences and Animal Physiology, including electrophysiology and cellular and molecular neurobiology. She or he will be involved in teaching and mentoring neurosciences and physiology skills, participate to international education and exchanges with foreign researchers involved in international training, and be associated with the development of innovative teaching tools (Tice, e-Learning, etc.) and continuing education. The courses concerned are the « Life Sciences », in particular « Biochemistry, Molecular Biology, Cellular and Physiology », « Sciences for Health » and the Master « Neurosciences » in the « Neuroscience molecular, cellular and integrated » course. Involvement is expected in international thematic schools and new translational training streams.Host Team: The candidate will develop his work in the laboratory of Neuronal and Neuroendocrine Cell Communication and Differentiation (Inserm U1239, Dir. Y. Anouar) whose research is focused on cerebral and neuroendocrine pathologies. The candidate will integrate the « Astrocyte and Vascular Niche » team (Dr. H Castel), whose work focuses on the cellular and pathophysiological mechanisms that control brain tumorigenesis (proliferation, migration, invasion, angiogenesis, resistance to treatment) and impact of cancer and/or cancer
therapies on the functions of the central nervous system. The general objective of the team is to understand the determinants of the invasion of the cerebral parenchyma by glial tumor cells
and to seek new therapeutic approaches by combining cellular and animal models up to clinical studies.

Contact: Dr Hélène Castel, DR2 Inserm
Tel : 33-2-35-14-66-30
Inserm U1239
Université de Rouen Normandie

02/08/2017 – Postdoc position in mammalian epigenetics, IGMM Montpellier

  • Type : Post-doc
  • Contrat : 24 months
  • Expected starting date : end of 2017/early 2018

Role of Pluripotency-Associated Proteins in Genomic Imprinting
This post-doctoral researcher position in epigenetics is at the Institute of Molecular Genetics (IGMM; http://www.igmm.cnrs.fr ) in Montpellier, France, and concerns the regulation of
genomic imprinting in mammals.

Imprinted genes play essential roles in development and disease. Their mono-allelic expression is regulated by differentially-methylated ‘imprinting control regions’ (ICRs). The allele-specific DNA methylation imprints at these ICRs are stably maintenance throughout development. It remains unknown, however, how the unmethylated alleles of ICRs are maintained and what protects these against de novo DNA methylation in the early embryo.

This post-doctoral project explores the role of different pluripotency-associated proteins that are expressed in embryonic stem and primordial germ cells. The goal of the research is to unravel the characteristics and role of these DNA binding proteins using WT and KO cells and expression constructs, and to explore in cells and embryos their effects on genomic imprinting. This research project uses the mouse as a model system and should enhance our understanding of genomic imprinting and its deregulation in congenital diseases and cancer.

The position is in the ‘Genomic Imprinting and Development’ group (head: Robert Feil), who are interested in recruiting a motivated candidate who is at an early stage after obtaining her/his Ph.D. degree, and has a strong background in molecular biology and experience in chromatin research and stem cell biology / embryology. Although not compulsory, skills in bioinformatics would ideally complement this profile.
The position is for 2 years and is expected to start the end of 2017/early 2018. The salary is provided by the University of Montpellier, in the context of the Laboratory of Excellence (Labex) EpiGenMed ( https://www.epigenmed.fr/ ).

Applicants should send their Curriculum Vitae, two references and a letter of motivation to Dr. Robert Feil, who can be contacted for informal inquiries as well.

Recent publications from the laboratory:
Llères D et al. (2017). Cell reports, 18, 1791-1803.
Auclair G et al. (2016). Genome Research, 26, 192-202.
Puget N et al. (2015). Mol. Cell. Biol. 35, 529-543.
Kota SK et al. (2014). Developmental Cell, 31, 19-33.
Girardot M et al. (2014). Nucleic Acids Res., 42, 235-248.
Kelsey G & Feil R (2013). Phil. Trans. R. Soc. B, 368, 20110336.

02/07/2017 – Postdoc position quantitative neuronal cell biologye, University of Bern, Switzerland

  • Type : Post-doc
  • Contrat : 24 months

I am looking for an ambitious postdoc that is interested in studying spatio-temporal Rho GTPase during neuronal guidance (live cell FRET imaging, computer vision techniques, …). The position is funded for an initial period of two years.

The cellular dynamics lab (http://www.izb.unibe.ch/research/prof_dr_olivier_pertz/index_eng.html) studies spatio-temporal signaling networks that regulate cytoskeletal dynamics (during cell migration or neuronal differentiation), or the control of cell fate decisions. For that purpose, we utilize state of the art imaging techniques to visualize signaling activities in single living cells, microfluidics technology to precisely manipulate these cells, computer vision approaches for automated analysis of our imaging datasets, and mathematical modeling to extract meaningful
insights from our experiments.
The project deals with the identification of spatio-temporal Rho GTPase signaling network regulating neuronal growth cone motility and neurite outgrowth dynamics. The project will involve imaging spatio-temporal patterns of Rho GTPase activity using FRET probes in live neuronal growth cones, siRNA perturbations and automated image analysis. The goal of the project is to
formulate a model of spatio-temporal Rho GTPase signaling regulating cytoskeletal dynamics in neuronal motility. This position is funded by the Swiss National Foundation, and takes place in
collaboration with the lab of Alfredo Caceres at the National University of Cordoba, Argentina.

Please look at recent relevant publications:
A versatile toolkit to produce FRET-based biosensors to visualize signaling events in time and space. Science Signaling. 2013 Jul 23;6(285).
SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion. Developmental Cell. 2015 Oct ;35(1):78-92.
Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling. J Cell Biol. 2016 Jan 4;212(1):91-111.

Candidates with a PhD Degree in Biology, Biochemistry, Bioengineering or a closely related field should apply. Experience with molecular biology, cell culture, live cell imaging and programing are
advantages, but are not an absolute requirement. The postdoc is expected to interact with mathematicians that will perform modeling/image analysis. Excellent spoken and written English
are required. Only short-listed candidates will be contacted.
We offer a vibrant and collegial research environment consisting of international students and PIs, and an outstanding research infrastructure, especially when it comes to live cell imaging. The
position is funded for two years. Competitive salaries are awarded according to regulations from the Swiss National Science Foundation.
Applications with a full CV, references and a cover letter with a short research statement should be
submitted by email to Olivier Pertz

21/07/2017 – Postdoc position in RNA biology, Institut de Biologie de l’Ecole Normale Supérieure – Paris

  • Type : Post-doc
  • Contrat : 24 months
  • Expected starting date : preferentially before 2018

« Destiny of mRNAs & genetic diseases »

A postdoctoral position is available in the Functional Genomics section of Institut de Biologie de l’ENS in Paris, France. The team investigates RNA-­protein complexes that dictate the destiny of messenger RNAs, notably their quality control and their cellular localization in different cellular models including human cell lines and differentiating neural stem cells (https://www.ibens.ens.fr/spip.php?rubrique42). A particular emphasis is given onto RNA helicases that are molecular motors ensuring RNP complex dynamics. Multiple research approaches are combined, from biochemistry to single molecule biophysics, molecular and cellular biology as well as transcriptomics.

More information

Contact: Hervé Le Hir, PhD E-­mail: lehir@ens.fr

Institut de Biologie de l’ENS, Functional Genomics
CNRS UMR8197 – INSERM U1024
46, rue d’Ulm – 75230 Paris cedex 05 -­ France
Tel : 01 44 32 39 45

21/07/2017 – Postdoc position – Functions of the piRNA pathway in germline stem cells, IGH UMR9002 CNRS-UM, Montpellier

  • Type : Post-doc
  • Contrat : 24 months
  • Expected starting date : October 1st, 2017

A two-year post-doctoral position funded by the Labex EpiGenMed is available in the group mRNA Regulation and Development at the Institute of Human Genetics in Montpellier. Our lab works on gene regulation at the mRNA level during development and diseases, in the Drosophila model. We have described the role of Piwi-interacting RNAs (piRNAs), a specific class of small non-coding RNAs, in gene regulation for several developmental processes. This function was unexpected because piRNAs were thought to be specific to the regulation of transposable elements. piRNAs and PIWI proteins are highly expressed in germ cells and stem cell lineages. The post-doctoral project aims at understanding the functions of the piRNA pathway in stem cells, using germline stem cells as a model system.

More information

Contact: Martine Simonelig e-mail: Martine.Simonelig@igh.cnrs.fr

mRNA Regulation and Development
Department Genetics and Development
Institute of Human Genetics, Montpellier, France

 

30/06/2017 – Postdoc position in viro-immunology, CIRI, Center for, Infectiology Research, Lyon

  • Type : Post-doc
  • Contrat : 24 months

We are currently inviting applications from enthusiastic and independent post-doctoral candidates to participate in our
ANR LabEx-funded project (a fully funded 2-year postdoc position).
The research program centers on viruses of the flaviviridae family (Dengue, zika virus, HCV) and the activation of the innate immune response via the sensing of infected cells, as well as viral strategies for immune
evasion.

More information

CIRI, Center for Infectiology Research
INSERM U1111–CNRS UMR5308 – Université
Lyon 1– ENS Lyon, France http://ciri.inserm.fr/team/all-teams/

Please send one PDF file to Marlene Dreux marlene.dreux@ens-lyon.fr containing the following:
– cover letter (with short statement of the research interests)
– concise summary of previous research activities
– curriculum vitae including publication list and contact details for 2-3 referees

23/06/2017 – Postdoc- Post-translational modifications of the LUBAC – INSERM U1232, Nantes

  • Type : Post-doc
  • Contrat : 12 months (with possible extension one year)
  • Provisional Start Date: 02/01/2018
  • Application deadline: 15/11/2017

Please find here a post-doc position open in Cell Biology and Cancer Research, Nantes, France.

The post-doctoral fellow will investigate how post-translational modifications of the linear ubiquitin assembly complex (LUBAC) regulate its functions in physiological and physio-pathological conditions. The proposed project combines high throughput unbiased screens (proteomic, genomic and chemical) with classical biochemistry and cell biology, as well as integrated models (mouse models and clinical data).

keywords: Signal transduction, Ubiquitin, NF-KkB, cancer, cell death

16/06/2017 – Postdoc- Stem Cell and Myelin Repair – Institut du Cerveau et de la Moelle épinière, Paris

  • Type : Post-doc

A post-doctoral fellowship   The Institut du Cerveau et de la Moelle épinière (ICM), offers A post-­‐doctoral fellowship (3 to 5 years expérience) in: « Stem Cell and Myelin Repair » CDD (m/f) Paris 13 Arr. The Institut du « Cerveau et de la Moelle épinière » is a private foundation, which objective is fundamental and clinical research of the nervous system. Reunited in one site, 600 researchers, ingenieurs et clinicians cover most of the disciplines in Neurology with the aim to accelerate discoveries in brain functioning, and developments of treatment for diseases such as: Alzheimer, Parkinson, Multiple Sclerosis, epilepsy, depression, paraplegia, tetraplegia, etc.

More information

CV to send to : anne.baron@upmc.fr (ou) or by postal mail to « Service recrutement, Poste « Stagiaire Post–doctoral : Cellules souches et Réparation de la Myéline » (m/f) : ICM –‐ Hôpital Pitié Salpêtrière 47 Boulevard de l’Hôpital –‐ 75013 Paris

29/05/2017 – Postdoctoral position INSERM U1211-MRGM (Rares Diseases, Genetic and Metabolism) in Bordeaux, France

  • Type : Post-doc
  • Contrat : 24 months (with possible extension a third year)
  • Provisional Start Date: October 1st, 2017

We offer a 2-years postdoctoral position (with possible extension to a third year)
for a project related to host-pathogen metabolic interactions. The project involves
classical immunology approaches as well as proteomics and metabolomics.

More information

Interested candidates may send their complete CV and at least one recommendation letter by July 1st, 2017 to: Johan Garaude (johan.garaude@inserm.fr)

17/05/2017 – Post-doctoral fellowship in the laboratory of retinal genetics at the INM, France

  • Type : Post-doc
  • Contrat : 24 months starting in the first semester of 2017

Postdoctoral Scientist in Neural Stem Cell Biology Institute for Neurosciences of Montpellier.

Applications are invited for a postdoctoral research scientist to join the “Brain plasticity, stem cells and gliomas” (Pr H Duffau) at the institute for neurosciences of Montpellier, France(INM). The research will be targeted towards deciphering and understanding the molecular events and signalling leading to activation of the neural stem cell niches, especially in the context of adult spinal cord pathologies. The project will involve various technologies including primary cell culture, FACS, transgenic animal, histology, cell imaging, bio-informatics and in vivo experiments in mice. Previous experience in stem cell biology and high-throughput approaches will be a plus.

More information

Application
Provide a letter that explains the reasons for being interested in this project, a CV with a list of publications, contact
details for three previous mentors. Application should be sent to contact@epigenmed.fr and to Christian Hamel
(christian.hamel@inserm.fr).

10/05/2017 – Postdoctoral Scientist in Neural Stem Cell Biology, Institute for Neurosciences of Montpellier, France

  • Type : Post-doc

Project: Genetics and pathophysiology of the age-related macular degeneration EMAP
EMAP (Extended Macular Atrophy with Pseudodrusen) is a rapid, bilateral geographic age-related macular
degeneration (retinal dystrophy) whose pathophysiology is unknown. We enrolled 115 EMAP patients and 345
matched controls and performed an epidemiological study which showed that EMAP is indeed different from the
classic age-related macular degeneration. We have performed a medium scale genetic case control association study
to search for genetic factors using 60 EMAP analyzed vs databases to search for disease causing variants. We now
need i) to examine the genetics variants found in EMAP patients ii) to evaluate the presence of the variants found in
age-related macular degeneration in EMAP patients.

More information

Applicants are invited to submit a full CV, a brief statement of research experience and interests and contact information for 2-3 potential referees, to Dr JP Hugnot (hugnot@gmail.com). The recruited candidate is expected to start as early as possible.

03/05/2017 – Postdoctoral Position in the Field of Molecular Immunology, IGBMC, Strasbourg, France

  • Type : Post-doc

The Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France, invites applications for a Postdoctoral Position in the Laboratory of Dr. Bernardo Reina-San-Martin. The IGBMC is one of the leading European centers of biomedical research. The institute provides access to state-of-the-art infrastructure and platforms, including transgenesis, nextgeneration sequencing, mass spectrometry, flow cytometry, imaging, highthroughput screening, etc.

More information

27/04/2017 – Postdoctoral position in Neurobiology, Institut Valrose, Nice

  • Type : Post-doc
  • Contrat : CDD

A new position in Neurobiology is available at the “Institut de Biologie Valrose” (iBV) located in Nice, France. The Institute of Biology Valrose (http://ibv.unice.fr/EN/index.php) is one of France’s premier life science research centers and offers an international scientific environment with 250 persons working in 20 research groups. The project will be carried out in the ATIP-Avenir/ FRM group “ Biology of ion channels” to investigate the role of K 2P potassium channels using new optogenetic approaches.

More informations

26/04/2017 – Postdoctoral fellowship for a project combining immunology and bio-informatics in Lisbon

  • Type : Post-doc
  • Contrat : CDD 12 months, possibly renewable

The AESOUSA laboratory of Human Immunodeficiency & Immune Reconstitution, at Instituto de Medicina Molecular, Lisbon is looking for a highly motivated and enthusiastic postdoctoral researcher to join our research team. The postdoctoral research fellow will work closely with the Primary Immunodeficiency Center team that includes physicians and researchers and which primary goal is to improve the assessment and care of patients with genetic defects of the immune system.

Work Plan: Analysis of NGS data from human samples and development of functional assays to validate the role of gene variants in the immune system.

More informations

20/04/2017 – Postdoctoral fellowship in Endothelial Autophagy and Artheosclerosis, INSERM UMR970, Paris

  • Type : Post-doc
  • Contrat : CDD 36 mois

A post-doctoral fellowship position is opening mid-2017 in the laboratory of Chantal Boulanger at the Paris Cardiovascular Research Center (Inserm UMR-970, Paris Descartes University).

The position is fully funded for 3 years and will remain open until filled.

More informations.

19/04/2017 – Postdoctoral Research Position on modeling the metabolic functions of the p53 pathway, Le Cam Laboratory, Montpellier Cancer Center

  • Type : Post-doc
  • Contrat : CDD 36 mois

The « Institut de Recherche en Cancérologie de Montpellier » (IRCM) is located on the campus of the regional cancer center ICM where ground breaking research in basic and translational oncology is developed in close collaboration with clinical departments (www.ircm.fr). Our laboratory is interested in molecular circuitries implicated in cellular senescence and stem cell function, and how perturbations of these biological processes affect organismal aging and tumorigenesis. Our project aims at characterizing new regulatory mechanisms of the p53 pathway, one of the most commonly inactivated tumor suppressor pathway. In the past years, we identified atypical functions of important components of the p53 pathway (p53, MDM2, E4F1) in metabolism and found that perturbations of these metabolic networks impinge on stem cell maintenance, cellular senescence, normal tissue homeostasis and cancer development.

Plus d’informations

13/04/2017 – Post-doc in Alexey Glukhov’s lab, Wisconsin

  • Type : Post-doc

Alexey Glukhov is currently looking for a postdoc to join his lab in Wisconsin: https://www.medicine.wisc.edu/people-search/people/staff/5065/Glukhov_Alexey

Actually, we are looking for someone with experience in confocal microscopy and fluorescent imaging from live cells, like to measure calcium transients and action potentials from live cardiomyocytes, or stem cells and intact tissues. Like cardiac electrophysiology and optical mapping/confocal imaging. We have here several systems for different imaging, including IonOptics for simultaneous contraction and calcium transient imaging, confocal microscope for calcium transients/sparks recordings (similar to what Markus was doing at Ken’s lab), and the whole-heart optical imaging.

This position will be supported from two sources: primarily by the UW2020 initiative (here is a link on it https://research.wisc.edu/funding/uw2020/round-1-projects/patient-specific-ventricular-cardiac-tissue-units-for-sudden-cardiac-death-prevention/ ) and by a couple of other grants between Drs. Timothy Kamp (https://www.medicine.wisc.edu/people-search/people/staff/138/Kamp_Timothy) and Alexey Glukhov (https://www.medicine.wisc.edu/people-search/people/staff/5065/Glukhov_Alexey). We are looking for someone with experience in cardiac electrophysiology, confocal imaging of live cells, and fluorescent optical mapping of cardiac tissues.

13/04/2017 – Junior Group Leader Recruitments at Helmholtz Center, Munich

  • Type : Junior group leader

After successfully launching a call last year, we have a second call for a Junior group leader position opening at the Institute of Epigenetics and Stem Cells at the Helmholtz Zentrum (www.hmgu.de/ies).

See detail: https://bms.candibase.de/atool/helmholtz/frontend.php?view=800ccd358c73232aeb548d688eef4e5d&lang=en&

07/04/2017 – Postdoctoral position: membrane remodelling and disruption of cadherin-mediated intercellular adhesion in cancer cells, CRBM, Montpellier, France

  • Type : Postdoctoral Position
  • Contrat : CDD 24 mois

A 24 months postdoctoral position is available starting from September/October 2017 in our group, based at the CRBM, Montpellier, France (http://www.crbm.cnrs.fr/index.php/fr/). Current work in the lab analyzes how the upregulation flotillins, new metastatic markers, disrupt cadherin-mediated intercellular adhesion and deregulate intravesicular trafficking to favor cellular invasive behavior.

Plus d’informations

06/04/2017 – Postdoctoral Research Position on Superresolution analysis of key-players in Alzheimer’s disease pathogenesis, KU Leuven, Belgium

  • Type : Postdoctoral Position
  • Contrat : CDD 36 mois
  • Open position: September/October 2017

The VIB Center for Brain and Disease Research (KU Leuven, Belgium), headed by Prof. Patrik Verstreken, is a vibrant and international research centre where key issues relevant for major human neurodegenerative diseases are tackled. The laboratory for Membrane Trafficking (Prof. Wim Annaert) studies the cellular biology of Alzheimer’s disease (AD) and aims to understand how intracellular transport regulation contributes to intramembrane proteolysis of APP and the production of neurotoxic Aβ peptides. Recent work from the lab (Sannerud et al., Cell, 2016) showed that PSEN2/γ-secretase generates the prominent pool of intracellular Aβ and familial AD-associated mutations strongly increase the accumulation of longer Aβ. Herein it was striking to find PSEN2 complexes organized in nanodomains on the limiting endosomal/lysosomal membrane. This project will focus on exploring this nanodomain organization of PSEN/γ-secretase complexes in cellmodels including differentiating neurons using subdiffraction microscopy or nanoscopy. The laboratory has in-house PALM/STORM
and SIM microscopy and closely collaborates with spectroscopists Prof. Johan Hofkens and Prof. Hideaki Mizuno in the Science and Technology group at KU Leuven to improve nanoscopy modalities and explore novel fluorescent probes. The project is focused on superresolution analysis but bridges with basic neuro- and lysosomal biology in the context of Alzheimer’s disease pathogenesis.

Plus d’informations

06/04/2017 – Post-doc position in Neurosciences, GIN – Inserm 1216, Humbert’s lab,Grenoble, France

  • Type : Postdoctoral Position
  • Contrat : CDD 36 mois
  • Open position: Fall 2017

While Huntington’s disease (HD) is a neurological disorder with late manifestation, there is evidence
that huntingtin, the protein causing HD, participates to several steps of cortical development. These
mechanisms are deregulated in HD conditions leading to abnormal cortical development. The goal of
the postdoctoral project is to further study the molecular mechanisms by which HTT mediates its role
during brain development and to assess how this may impact on adult brain and behavior.

Plus d’informations